Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s. Approximately 1% of people over 65 and 3% over 75 are affected. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson’s disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 is similar to its human counterpart. Synphilin-1 plays an important role in aggregate formation and cytotoxicity in Parkinson’s disease, and Dorfin may be involved in the pathogenic process through ubiquitylation of synphilin-1. It is implicated in synaptic function, protein degradation, and the molecular mechanisms leading to neurodegeneration in Parkinson’s disease.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.