Thermo Fisher Scientific CLEC2D Monoclonal Antibody (4C7)
CLEC2D 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot, IHC, ELISA에 사용 가능. 인간 시료 반응성. PBS 기반 용액 형태로 제공되며 보존제 미함유. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C7 |
| Immunogen | CLEC2D (AAH19883, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MHDSNNVEKD ITPSELPANP GCVHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQ
Target Information
Zhou et al. have identified a protein that inhibits multinucleate osteoclast formation in murine osteoblast and spleen cell co-cultures. This protein, named Osteoclast Inhibitory Lectin (OCIL), also suppresses osteoclast formation in spleen cell cultures treated with RANKL and M-CSF.
mOCIL acts directly on macrophage/monocyte cells, showing inhibitory effects even when stromal and lymphocytic cells are removed.
It completely inhibits osteoclast formation during the proliferative phase and shows about 70% inhibition during differentiation.
OCIL mRNA expression in osteoblasts is enhanced by parathyroid hormone, calcitriol, interleukin-1, IL-11, and retinoic acid.
OCIL is expressed in osteoblasts, chondrocytes, and various extraskeletal tissues.
Because OCIL expression is similar to RANKL distribution, it is suggested that OCIL and RANKL may interact in skeletal and extracellular tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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