Thermo Fisher Scientific ADAR1 Polyclonal Antibody
ADAR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합. E.coli 유래 재조합 항원으로 제작되었으며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Thermo Fisher Scientific ADAR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human ADAR1 recombinant protein (Position: S128–Q346) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745845 |
Product Specific Information
Human CRM1 shares 93.4% and 91.5% amino acid sequence identity with mouse and rat CRM1, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing.
This process affects gene expression and function in multiple ways, including:
- mRNA translation by altering codons and amino acid sequences
- pre-mRNA splicing by modifying splice site recognition
- RNA stability by changing nuclease recognition sequences
- genetic stability in RNA virus genomes
- RNA structure-dependent activities such as microRNA production or protein–RNA interactions
ADAR can edit both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing).
Cellular substrates include BLCAP, GRIA2, HTR2C, and GABRA3.
Viral substrates include HCV, VSV, MV, HDV, and HIV-1.
ADAR1 exhibits proviral or antiviral effects depending on the virus and mechanism (editing-dependent or independent).
It impairs HCV replication, enhances MV, VSV, and HIV-1 replication, and modulates HDV replication via A-to-I editing at the amber/W site.
High levels of ADAR1 inhibit HDV replication.
(Source: Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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