Thermo Fisher Scientific ADAR1 Polyclonal Antibody

Thermo Fisher Scientific ADAR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Human CRM1 shares 93.4% and 91.5% amino acid sequence identity with mouse and rat CRM1, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing.
This process affects gene expression and function in multiple ways, including:

• mRNA translation by altering codons and amino acid sequences
• pre-mRNA splicing by modifying splice site recognition
• RNA stability by changing nuclease recognition sequences
• genetic stability in RNA virus genomes
• RNA structure-dependent activities such as microRNA production or protein–RNA interactions

ADAR can edit both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing).
Cellular substrates include BLCAP, GRIA2, HTR2C, and GABRA3.
Viral substrates include HCV, VSV, MV, HDV, and HIV-1.
ADAR1 exhibits proviral or antiviral effects depending on the virus and mechanism (editing-dependent or independent).
It impairs HCV replication, enhances MV, VSV, and HIV-1 replication, and modulates HDV replication via A-to-I editing at the amber/W site.
High levels of ADAR1 inhibit HDV replication.
(Source: Uniprot)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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