Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Desmoglein 3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 및 랫트 시료 반응성이 있으며, 고순도의 Affinity 정제 항체입니다. 세포 간 접착 연구 및 pemphigus vulgaris 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DSG3 (Accession P32926), corresponding to amino acid residues K855–Q905 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899780 |
Product Specific Information
This antibody detects endogenous levels of total Desmoglein 3 (DSG3).
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), belongs to the desmosomal cadherin family and plays a crucial role in cell–cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 is identified as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies leads to loss of cell adhesion, clinically resulting in blisters and histologically in suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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