Thermo Fisher Scientific PNK Recombinant Rabbit Monoclonal Antibody (7J6Y6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7J6Y6

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 400-500 of Human PNKP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PNK,uniProtId:Q96T60-1,ncbiNodeId:9606,antigenRange:400-500,antigenLength:521,antigenImageFileName:MA5-55330_PNK_Q96T60-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55330_PNK_Q96T60-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: GSWQRCVTTC ETALKQGKRV AIDNTNPDAA SRARYVQCAR AAGVPCRCFL FTATLEQARH NNRFREMTDS SHIPVSDMVM YGYRKQFEAP TLAEGFSAIL E

Target Information

Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5-hydroxy and 3-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.