Thermo Fisher Scientific LST1 Monoclonal Antibody (LST1/02)
LST1 단백질의 세포외 에피토프를 인식하는 Mouse monoclonal antibody. Human 시료에 반응하며 WB, ICC/IF, IP에 사용 가능. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공. 4°C 보관, 동결 금지.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LST1/02 |
| Immunogen | KLH-fused peptide corresponding to amino acids SSEGPDLRGRDKRGT of human LST1 (aa 66–80) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157626 |
Product Specific Information
This antibody reacts with an extracellular epitope of LST1, an approximately 6–11 kDa protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS-PAGE gels as an approximately 25–28 kDa molecule.
Target Information
LST1 (leukocyte-specific transcript, also known as B144) is expressed in cells of myeloid/erythroid lineage including monocytes, granulocytes, dendritic cells, platelets, and erythrocytes.
At least 14 alternatively spliced variants (LST1/A–LST1/N) can be detected; some (LST1/A, B, C, G, I, K) are transmembrane forms, while others are soluble.
LST1 induces formation of long, thin filopodia in dendritic cells, inhibits lymphocyte proliferation, and may play an immunomodulatory role.
LST1/A is an 11 kDa transmembrane adaptor present in membrane rafts, forming spontaneous covalent homodimers. Its intracellular domain contains two tyrosine motifs, one of which is an ITIM similar to motifs in Siglec.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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