Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 인식하는 Rabbit Polyclonal Antibody로서 Human, Mouse, Rat 시료에 반응. WB, IHC, Flow Cytometry 등에 사용 가능. Protein A로 정제된 액상 형태이며, 안정적인 저장을 위한 50% glycerol 및 ProClin 300 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MTM1/Myotubularin, amino acids 225–275 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy.
Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and regulates the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking.
Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro, thereby decreasing PI 3-P levels by down-regulating PI 3-K activity and facilitating PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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