Thermo Fisher Scientific MBD4 Polyclonal Antibody
Human MBD4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 연구용으로 DNA 메틸화 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MBD4 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736119 |
Product Specific Information
- Positive Control: 3xFlag-human MBD4-transfected 293T
- Predicted Reactivity: Chimpanzee (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DNA methylation, the addition of methyl groups to cytosine bases in CpG dinucleotides, is essential for proper development and gene expression regulation. The demethylation enzyme associated with a methyl-CpG-binding domain (MBD) can revert methylated cytosine bases to cytosines by cleaving the methyl group as methanol.
MeCP2 and MBD1 repress transcription by binding to methylated DNA, while MBD2 and MBD4 (also known as MED1) colocalize with methylated satellite DNA, mediating methylation signal functions.
MBD3 does not bind methylated DNA. MBD1–MBD4 are expressed in somatic tissues, though MBD1 and MBD2 expression is reduced or absent in embryonic stem cells lacking MeCP1 activity.
MBD4 shares homology with bacterial base excision repair DNA N-glycosylases/lyases and is known to be mutated in some microsatellite unstable tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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