Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody
Human DSG3 인식 토끼 폴리클로날 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 세포 간 접착 단백질 Desmoglein 3 검출에 적합하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC(P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DSG3 (amino acids 383–490) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791468 |
Product Specific Information
Immunogen sequence:
FRPASKTFTV QKGISSKKLV DYILGTYQAI DEDTNKAASN VKYVMGRNDG GYLMIDSKTA EIKFVKNMNR DSTFIVNKTI TAEVLAIDEY TGKTSTGTVY VRVPDFND
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 is the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, clinically manifesting as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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