Thermo Fisher Scientific ACVR1B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–15 µg/mL

ELISA

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.