Thermo Fisher Scientific EIF2AK1 Polyclonal Antibody
EIF2AK1 (HRI) 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 5–15 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1, HRI) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
EIF2AK1 (HRI) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stresses, leading to reduced protein synthesis.
Signaling is initiated by low levels of heme. The HRI gene is localized to 7p22, where its 3′ end slightly overlaps the 3′ end of the JTV1 gene. Both genes are transcribed from opposite strands.
Kinase activity is induced by low heme levels and inhibited by the presence of heme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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