Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser118) Polyclonal Antibody
Phospho-Estrogen Receptor alpha (Ser118) 항체로, 인간, 마우스, 랫트 시료에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합하며, Rabbit Polyclonal 형식입니다. Protein A로 정제된 1 mg/mL 액상 제품으로, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human ER alpha around the phosphorylation site of Ser118 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are part of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor; when bound to estrogen, it undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. This binding can either activate or repress gene transcription through interaction with coactivator or corepressor proteins.
There are two main forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four isoforms of estrogen receptor-alpha exist (Isoforms 1: 66 kDa, 2: 53 kDa, 3: 47 kDa, 4: 35 kDa). Estrogen receptors are widely expressed across tissues and are crucial for sexual development, reproductive function, and bone metabolism. They are also involved in pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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