Thermo Fisher Scientific Phospho-GSK3 alpha/beta (Tyr279, Tyr216) Polyclonal Antibody
GSK3 α/β 인산화형(Tyr279/216)을 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human GSK3 alpha around the phosphorylation site of Tyrosine 279 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553634 |
Product Specific Information
This antibody detects endogenous protein at molecular weights of 46 and 51 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Glycogen synthase kinase-3 (GSK3) is a protein kinase originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism.
It participates in regulating various cellular processes, including protein synthesis, cell proliferation, differentiation, microtubule assembly/disassembly, and apoptosis.
GSK3 phosphorylation occurs only when a phosphoserine or phosphotyrosine residue is present four residues C-terminal to the phosphorylation site.
Two isoforms exist: GSK3 alpha and GSK3 beta. Both are regulated by phosphorylation:
- Inactivation: Phosphorylation of GSK3β on Ser9 (Ser21 in GSK3α) by PKB.
- Activation: Phosphorylation of GSK3β on Tyr216 (Tyr279 in GSK3α).
Activated GSK3β phosphorylates several proteins, including p53, c-Myc, c-Jun, HSF-1, and cyclin D1.
It also phosphorylates tau protein at aberrant sites, contributing to Alzheimer’s disease progression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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