Thermo Fisher Scientific GEMIN8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GEMIN8.

Target Information

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. It plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
In the cytosol, the Sm proteins (SNRPD1, SNRPD2, SNRPE, SNRPF, and SNRPG) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A, which controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-103503_GEMIN8_Q9NWZ8-1_Rabbit.svg, PA5-103503_GEMIN8_Q9NWZ8-1_Rabbit_PDP.jpeg)