Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Concentration: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
RKASAVIHDQ HKLSTEETEI SPPLVKCGSA YEPENQSKDF LNKTFSDPHG RKVEKTTPDC QLRAFHLQSS AAESKPEEQV SGLNRTSSQG PEERSEYLK

Target Information

Parkinson disease is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting approximately 1% of individuals over 65 and 3% over 75 years old.
Synuclein alpha interacting protein (Synphilin-1) contains multiple protein-protein interaction domains and interacts with alpha-synuclein in neurons. Mutations in SNCAIP have been linked to Parkinson disease.
Synphilin-1 shows high homology with its human counterpart, particularly in ankyrin-like motifs and coiled-coil domains. Expression patterns in mouse tissues are similar to those in humans.
Synphilin-1 plays a key role in aggregate formation and cytotoxicity in Parkinson disease, and Dorfin may contribute to the pathogenic process via ubiquitylation of Synphilin-1. It is also involved in synaptic function, protein degradation, and neurodegenerative mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.