Thermo Fisher Scientific RND2 Polyclonal Antibody

Applications

Tested Applications and Dilutions

• Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
GCKLDMRTDL ATLRELSKQR LIPVTHEQGT VLAKQVGAVS YVECSSRSSE RSVRDV

Target Information

The Ras p21 family of guanine nucleotide proteins has been widely studied due to its role in signal transduction and frequent mutations in human malignancies. Ras proteins (H-, K-, and N-Ras p21) are part of a larger superfamily of related proteins.
Six members—Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A, and Ral B—show approximately 50% amino acid homology to Ras.
The six mammalian Rho proteins (Rho A, B, C, G, 7, and 8) are about 30% homologous to Ras and are expressed in a wide range of cell types.
Both Ras p21 and Rho p21, along with other Ras superfamily members, contain a carboxy-terminal CAAX sequence (C: cysteine; A: aliphatic amino acid; X: any amino acid), which is essential for proper localization and function in Ras.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.