Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, store aliquots at -20°C for higher stability, or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s, affecting about 1% of people over 65 and 3% over 75. Mutations in SNCAIP, encoding synuclein alpha interacting protein (Synphilin-1), are linked to Parkinson’s disease. Synphilin-1 interacts with alpha-synuclein in neurons and contains multiple protein-protein interaction domains, including ankyrin-like motifs and coiled-coil regions. Expression patterns in mouse and human tissues are similar. Synphilin-1 plays a role in aggregate formation, cytotoxicity, and may be ubiquitylated by Dorfin in the pathogenic process. It is involved in synaptic function, protein degradation, and neurodegeneration mechanisms in Parkinson’s disease.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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