Thermo Fisher Scientific Relaxin 1 Monoclonal Antibody (351713)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

351713

Immunogen

E. coli-derived recombinant human Relaxin-1 Lys26-Cys185 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Relaxin 1,uniProtId:P04808-1,ncbiNodeId:9606,antigenRange:26-185,antigenLength:185,antigenImageFileName:MA5-24094_Relaxin_1_P04808-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24094_Relaxin_1_P04808-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609733

Product Specific Information

This antibody detects the precursor form of human Relaxin-1 in direct ELISAs and Western blots. This antibody does not detect mature Relaxin-1 heterodimer. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Relaxin-2 precursor or rhRelaxin-3 precursor is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.