Thermo Fisher Scientific UBE3A/E6-AP Monoclonal Antibody (PCRP-UBE3A-1A2)
UBE3A/E6-AP 단백질을 인식하는 Mouse Monoclonal Antibody. ICC/IF, Flow Cytometry, Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상형 항체로, 4°C에서 보관. 인간 UBE3A 단백질 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-UBE3A-1A2 |
| Immunogen | Recombinant full-length human UBE3A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
UBE3A (ubiquitin-protein ligase E3A, also known as E6AP) is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 enzyme to substrate proteins. Identified substrates include ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, PML tumor suppressor, and CDKN1B. UBE3A may act as a cellular quality control ligase by promoting degradation of misfolded cytoplasmic proteins and is involved in circadian clock regulation. Defects in UBE3A are associated with Angelman syndrome (AS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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