Thermo Fisher Scientific Contactin 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is >95% (by SDS-PAGE).

Target Information

Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences axon connection formation in the developing nervous system.
It is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol anchor, six Ig-like domains, and four Fibronectin type III (FNIII)-like domains.
Contactin 2 is expressed predominantly during neural development on axonal membranes to guide commissural axons without promoting growth.
It binds with NgCAM in cis-binding mode on the same membrane, and heterophilic binding sites (Contactin 2/NgCAM, Contactin 2/NrCAM) are localized to the first four Ig domains, while homophilic binding (Contactin 2/Contactin 2) occurs at the FNIII domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.