Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody
Thermo Fisher Scientific의 GUCY1B3 Polyclonal Antibody는 인간 GUCY1B3 단백질을 인식하는 토끼 다클론 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GUCY1B3. Recombinant protein control fragment (Product # RP-90697) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789892 |
Product Specific Information
Immunogen sequence:
HALELLVIRN YGPEVWEDIK KEAQLDEEGQ FLVRIIYDDS KTYDLVAAAS KVLNLNAGEI LQMFGKMFFV FCQESGYDTI LRVLGSNVRE FLQNLDALHD HLATIYPGMR APSFRCTDAE KGKGLILHYY SEREGLQDIV IGII
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:
- A soluble form (GCS or sGC) that acts as a receptor for nitric oxide
- A membrane-bound receptor form (GC) that functions as a peptide hormone receptor
The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain.
It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP.
GC-C acts as a receptor for heat-stable enterotoxins secreted by some pathogenic E. coli strains and also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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