Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
HALELLVIRN YGPEVWEDIK KEAQLDEEGQ FLVRIIYDDS KTYDLVAAAS KVLNLNAGEI LQMFGKMFFV FCQESGYDTI LRVLGSNVRE FLQNLDALHD HLATIYPGMR APSFRCTDAE KGKGLILHYY SEREGLQDIV IGII

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:

• A soluble form (GCS or sGC) that acts as a receptor for nitric oxide
• A membrane-bound receptor form (GC) that functions as a peptide hormone receptor

The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain.
It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP.
GC-C acts as a receptor for heat-stable enterotoxins secreted by some pathogenic E. coli strains and also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.