Thermo Fisher Scientific MDMX Polyclonal Antibody
Rabbit polyclonal antibody against human MDMX (MDM4). Validated for Western blot. Recommended positive controls: HepG2, MCF-7. Predicted cross-reactivity with several species. Supplied as liquid, 0.5 mg/mL, stored at 4°C or -20°C.
- 카탈로그번호
- PA127958
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested dilution: 0.2–2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a N-terminal region of Human MDM4 (MDMX, UniProt ID: O15151-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2143693 |
Product Specific Information
- Recommended positive controls: HepG2, MCF-7
- Predicted reactivity: Cow (80%), Dog (93%), Horse (93%), Pig (86%), Rabbit (80%)
- Use at a concentration of 1 µg/mL in 5% skim milk/PBS buffer
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 through distinct interactions. The MDMX gene is often amplified in malignant gliomas. ARF binds and sequesters MDMX within the nucleolus, leading to increased p53 transactivation. Expression of MDMX can reverse MDM2-mediated p53 degradation while maintaining suppression of p53 transactivation. MDMX also binds and stabilizes p73, increasing its half-life in contrast to p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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