Thermo Fisher Scientific beta-Arrestin 2 Polyclonal Antibody
beta-Arrestin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA에 적합. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 300–400 of human ARRB2 (NP_0043041) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.89 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804756 |
Product Specific Information
- Immunogen sequence: NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM K
- Positive Samples: U-251MG, A-549
- Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, Clathrin-coated pit
Target Information
Beta-arrestin-2 (ARRB2) is an adaptor protein in the arrestin family with N- and C-arrestin domains. It regulates G protein-coupled receptor desensitization, particularly beta2-adrenergic receptor (beta2AR) function, by enhancing beta2AR-mediated nuclear translocation of ERK. ARRB2 binds phosphorylated beta2ARs, impairing their G(S) protein activation capacity. Together with AIP4, ARRB2 mediates CXCR4 endosomal sorting into a degradative pathway and may participate in hormone-specific desensitization of TSH receptors. It acts as a Ca²⁺ binding protein in retinal outer segments, interacts with P-rhodopsin, and contributes to synaptic transmission in photoreceptor cells. ARRB2 is widely expressed, notably in neuronal tissues and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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