Thermo Fisher Scientific CD81 Polyclonal Antibody
Rabbit polyclonal antibody against human CD81. Validated for Western blot (1:1,000–1:3,000). Detects endogenous CD81 protein. Suitable for research use in cell signaling, adhesion, and viral receptor studies. Supplied as liquid, 1 mg/mL in PBS with 50%...
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD81 (Accession P60033), corresponding to amino acid residues G112–L162 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899629 |
Product Specific Information
This antibody detects endogenous levels of total CD81.
Target Information
CD81 (also known as TAPA-1) is a member of the tetraspanin family expressed on most nucleated cells, particularly germinal center B cells. It forms complexes with other tetraspanins, integrins, coreceptors, and MHC molecules, influencing cell adhesion, morphology, activation, proliferation, and differentiation of B and T cells.
In muscle tissue, CD81 promotes cell fusion and myotube maintenance. It also serves as a receptor for the hepatitis C virus (HCV).
Like other tetraspanins (CD9, CD37, CD53, CD63, CD82), CD81 is a cell-surface glycoprotein with four hydrophobic domains and mediates signal transduction events related to cell development and motility.
CD81 associates with CD19, CD21, Leu 13, and integrins on the cell membrane, contributing to immune signaling and viral entry. Antibodies to CD81 can exhibit anti-proliferative effects on lymphoid cell lines and may have implications in tumor biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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