Thermo Fisher Scientific EFCAB4B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human EFCAB4B. Recombinant protein control fragment (Product #RP-97745). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:EFCAB4B,uniProtId:Q9BSW2-2,ncbiNodeId:9606,antigenRange:4-98,antigenLength:731,antigenImageFileName:PA5-58493_EFCAB4B_Q9BSW2-2_Rabbit.svg,antigenImageFileNamePDP:PA5-58493_EFCAB4B_Q9BSW2-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640910

Product Specific Information

Immunogen sequence: PDGRVVSRPQ RLGQGSGQGP KGSGACLHPL DSLEQKETQE QTSGQLVMLR KAQEFFQTCD AEGKGFIARK DMQRLHKELP LSLEELEDVF DALDA

Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 59%.

Target Information

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.