Thermo Fisher Scientific hSET1B Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger immune response.
VISA is a mitochondrial membrane protein identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to activation of NF-kappa-B. VISA interacts with components of the innate immune pathway such as TRIF, TRAF2, and TRAF6, and also with IKK-a, IKK-b, and IKK-iota kinases through its C-terminal region.
Cleavage of this region by Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. At least three isoforms of VISA are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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