Thermo Fisher Scientific ST2 Polyclonal Antibody
Rabbit polyclonal antibody targeting mouse IL1RL1 (ST2). Validated for Western blot applications. Supplied as unconjugated liquid at 1 mg/mL concentration. Suitable for research use in immunology and cytokine signaling studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within mouse IL1RL1 (aa 13–62) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802697 |
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of three Ig-like domains that interact with the co-receptor IL-1RAcP and the ligand IL-33. IL-33 binding activates adaptor proteins (MyD88, IRAK1, IRAK4, TRAF6), leading to NF-κB and MAPK pathway activation and release of cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two common isoforms of IL-33R arise from alternative splicing:
- ST2L: membrane-bound form
- ST2S: soluble form acting as a decoy receptor
IL-33R is primarily expressed by mast cells, basophils, eosinophils, and in mice, also on ILC2 and Th2 cells. IL-33R signaling is implicated in immune conditions including allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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