Thermo Fisher Scientific ZEB1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
• Predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Crab-eating macaque, and White-tufted-ear marmoset (based on 100% sequence identity)

Target Information

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression.
It can enhance or repress ATP1A1 promoter activity depending on cDNA quantity and cell type.
ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.
It also represses BCL6 transcription in the presence of CTBP1 and regulates neuronal differentiation by repressing RCOR1 activation during neurogenesis.
Mutations in ZEB1 are associated with corneal dystrophies such as posterior polymorphous and Fuchs endothelial corneal dystrophy type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.