Thermo Fisher Scientific GCK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
RMCVNTEWGA FGDSGELDEF LLEYDRLVDE SSANPGQQLY EKLIGGKYMG ELVRLVLLRL VDENLLFHGE ASEQLRTRGA FETRFVSQVE SDTGDRKQIY NILSTLGLRP STTDCDIVRR ACESVSTRAA HMCSAGLAGV INRMRESRSE DVMRITVGVD GSVYKLHPSF KERFHASVRR LTPSCEITFI ESEEGSGRGA ALVSAVACKK ACMLGQ

Positive Samples: LO2, A-549, mouse liver, rat liver
Cellular Location: Cytoplasm, Nucleus

Target Information

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase: one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. Unlike other hexokinases, this enzyme is not inhibited by glucose-6-phosphate and remains active when glucose is abundant. Mutations in this gene are associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young type 2 (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.