Thermo Fisher Scientific GABRA1 Monoclonal Antibody (N95/35), APC
GABRA1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체로, APC로 표지되어 형광 분석에 적합합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. 단백질 G로 정제된 액상 형태로 제공됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GABRA1 Monoclonal Antibody (N95/35), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N95/35 |
| Immunogen | Fusion protein amino acids 355–394 of human GABA-A-R-Alpha1 |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931939 |
Additional Formats
- Unconjugated (MA5-27703)
- FITC (MA5-45486)
- PE (MA5-45488)
- PerCP (MA5-45487)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45485 was sufficient for detection of alpha1 GABA receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 55 kDa. No cross-reactivity against GABA-A-R-Alpha2 or -Alpha3.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA_A receptor (GABA_A-R) subtype.
GABA_A-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABA_A-R is a multimeric subunit complex consisting of multiple alpha, beta, and gamma subunits with various splice variants. Expression of alpha- and beta-subunits results in functional GABA_A-Rs, while coexpression of a gamma-subunit is required for benzodiazepine modulation.
Phosphorylation of beta-subunits has been shown to modulate receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.