Thermo Fisher Scientific STK3 Monoclonal Antibody (4F7)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM SKNVFPDNWK V

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways and is activated by proapoptotic stimuli such as staurosporine and FAS ligand.
It functions as a stress-activated, pro-apoptotic kinase that, following caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
STK3/MST2 is a key component of the Hippo signaling pathway, regulating organ size and tumor suppression by restricting proliferation and promoting apoptosis.
In this pathway, STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1, which subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, controlling genes related to proliferation, apoptosis, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.