Thermo Fisher Scientific Phospho-CHK1 (Ser317) Polyclonal Antibody
인간 CHK1 단백질의 Ser317 인산화 형태를 검출하는 폴리클로날 항체. Western blot과 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. DNA 손상 체크포인트 연구 및 암세포 신호전달 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human Chk1 (phospho Ser317). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901979 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It is a key mediator in the DNA damage-induced checkpoint network and plays a critical role in maintaining genomic integrity under genotoxic stress.
When the G2 or S checkpoint is abrogated by CHK1 inhibition, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1 phase.
CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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