Thermo Fisher Scientific GITR Ligand/TNFSF18 Recombinant Rabbit Monoclonal Antibody (BLR211K)

Applications

• Western Blot (WB): 1:1,000 dilution

Product Specifications

Target Information

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-kappa-B and various mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is expressed on CD4+ CD25+ regulatory T cells and plays a key role in immune regulation. Its ligand, GITRL, is expressed in endothelial and antigen-presenting cells, activating NF-kappa-B, inducing both pro- and anti-apoptotic effects, inhibiting regulatory T cell suppression, and co-stimulating responder T cells through GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells significantly inhibited NF-kappa-B activation, suggesting that the GITRL–GITR pathway involves both NIK and TRAF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.