Thermo Fisher Scientific GITR Ligand/TNFSF18 Recombinant Rabbit Monoclonal Antibody (BLR211K)

Applications

• Western Blot (WB): Assay-dependent

Product Specifications

Target Information

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-kappa-B and mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is expressed on CD4+ CD25+ regulatory T cells and plays a crucial role in immune regulation.
Its ligand GITRL, expressed in endothelial and antigen-presenting cells, can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL–GITR pathway involves both NIK and TRAF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.