Thermo Fisher Scientific MPP5/PALS1 Polyclonal Antibody
다양한 종(Human, Mouse, Rat)에 반응하는 Rabbit Polyclonal 항체로, MPP5/PALS1 단백질 검출에 사용됩니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Protein A 정제 및 고순도 액상 형태로 제공됩니다. 세포 극성 연구 및 신경 발생 관련 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MPP5/PALS1 (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4) with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is essential for establishing and maintaining cell polarity in epithelial cells and neurons. It is a component of the Par-3 complex, contributing to tight junction maintenance in epithelial cells. Mutations in MPP5 are associated with neurologic impairments such as global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is involved in early differentiation of multipotent progenitors and supports lineage-specific contributions, particularly in myeloid and lymphoid cells. MPP5 variants can disrupt normal cellular function, leading to developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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