Thermo Fisher Scientific MEIS1 + MEIS2 Polyclonal Antibody
MEIS1 및 MEIS2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 안정적인 액상 형태로 제공.
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Applications 및 희석 배수
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MEIS2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MEIS1
Acts as a transcriptional regulator of PAX6 and activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development, and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in myeloid leukemia induction.
MEIS2
Involved in transcriptional regulation through binding to HOX or PBX proteins to form dimers or complexes with DNA-bound PBX/HOX dimers. Isoform 3 participates in PDX1:PBX1b:MEIS2b complex activity in pancreatic acinar cells. Also implicated in EPHA8 transcriptional activation and regulation of myeloid differentiation. Can bind and activate DRD1 promoter sequence 5'-TGACAG-3'; isoform 5 lacks this activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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