Thermo Fisher Scientific p38 MAPK Recombinant Rabbit Monoclonal Antibody (23GB4530)
Recombinant rabbit monoclonal antibody specific for p38 MAPK. Validated for WB, ICC/IF, and Flow Cytometry. High purity via affinity chromatography. Suitable for human, mouse, and rat samples. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB4530 |
| Immunogen | A synthesized peptide derived from human p38 MAPK (150–250 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other stimuli. p38 MAPK is inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, differing in tissue expression and affinity for activators and effectors. Activation occurs upon exposure to TNF, IL-1, heat shock, or other stimuli, leading to phosphorylation by MAPK kinase-3/6 at Thr180 and Tyr182. Activated phospho-p38 MAPK phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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