Thermo Fisher Scientific PACS1 Polyclonal Antibody
PACS1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, Western blot, IHC, ELISA 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, human, mouse, rat에 반응. 연구용으로 고품질 항체 제공.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | 2 µg/mL | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 17 amino acid peptide near the center of human PACS1 (amino acids 430–480) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718719 |
Target Information
PACS-1 (CRA_a) is a 963 amino acid regulatory protein involved in protein trafficking and belongs to the PACS family. It functions as a coat protein controlling the subcellular localization of trans-Golgi network (TGN) membrane proteins containing acidic cluster sorting motifs. PACS-1 is implicated in HIV-1 Nef-mediated removal of MHC-I from the cell surface to the TGN, aiding immune evasion. It also regulates endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by linking their acidic-cluster-containing cytoplasmic domains with the adapter-protein complex-1 (AP-1). PACS-1 is typically localized in the Golgi apparatus, trans-Golgi network, and paranuclear region, and is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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