Thermo Fisher Scientific MLH3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MLH3 for DNA mismatch repair research. Validated for Western blot applications. High purity via affinity chromatography. Supplied as liquid, unconjugated form with 0.5 mg/mL concentration. For research use only.
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Thermo Fisher Scientific MLH3 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.2–1 µg/mL
Publications: Refer to Thermo Fisher Scientific database.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human MLH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576714 |
Product Specific Information
- Peptide sequence: SMQVLQQVDN KFIACLMSTK TEENGEADSY EKQQAQGSGR KKLLSSTLIP
- Sequence homology: Human: 100%
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are involved in maintaining genomic integrity during DNA replication and meiotic recombination. The MLH3 protein functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations are associated with hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, with two full-length variants characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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