Thermo Fisher Scientific PROX1 Recombinant Rabbit Monoclonal Antibody (ARC1391)
PROX1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, ELISA에 적합. 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1391 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human PROX1 (Q92786) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.80 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849649 |
Product Specific Information
Immunogen sequence:
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN
Target Information
The expression pattern of the Prox1 homeobox gene suggests a role in various embryonic tissues, including the lens. Analysis of mRNA reveals that Prox1 mRNA is present in many human tissues, with the highest level in the lens. Homozygous Prox1⁻/⁻ mice die at midgestation from multiple developmental defects, including lens abnormalities. Prox1 inactivation causes abnormal proliferation, downregulation of Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis, leading to defective lens formation.
Prox1 is expressed in endothelial cell subpopulations that form the lymphatic system and is a key regulator of lymphatic development. It is also required for hepatocyte migration in mice; loss of Prox1 results in smaller livers with reduced hepatocyte clusters. In the embryonic mouse retina, Prox1 regulates progenitor cell cycle exit and differentiation, influencing proliferation and cell-fate determination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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