Thermo Fisher Scientific PCBP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: PHATHDLEGP PLDAYSIQGQ HTISPLDLAK LNQVARQQSH FAMMHGGTGF
• Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes.
The protein encoded by this gene appears to be multifunctional. Along with PCBP-2 and hnRNPK, it corresponds to the major cellular polydomains involved in RNA binding.
This encoded protein, together with PCBP-2, functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.
It is also implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.
Additionally, it plays a role in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.