Thermo Fisher Scientific CDNF/ARMETL1 Polyclonal Antibody
CDNF/ARMETL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간, 마우스, 랫트 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 고순도 항체입니다. 파킨슨병 연구 등 신경영양인자 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human ARMETL1 (amino acids 101–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to the mesencephalic astrocyte-derived neurotrophic factor. CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in the brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxydopamine (6-OHDA) induced degeneration of dopaminergic neurons in rat models of Parkinson’s disease. Furthermore, CDNF has been shown to restore dopaminergic function and prevent degeneration in the substantia nigra, suggesting potential therapeutic relevance for Parkinson’s disease. At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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