Thermo Fisher Scientific Human IL-27 Recombinant Protein, PeproTech
인간 유래 IL-27 재조합 단백질로 HEK293 세포에서 발현됨. 면역 반응 조절 및 T세포 분화 연구에 적합. SDS-PAGE 및 HPLC 기준 90% 이상 순도. TF-1 세포 증식 활성 검증 완료. 연구용으로만 사용 가능.
- 카테고리
- Protein
- 판매단위
- pk
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (13 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse |
| Expression System | HEK293 cells |
| Amino Acid Sequence | p28 subunit: FPRPPGRPQL SLQELRREFT VSLHLARKLL SEVRGQAHRF AESHLPGVNL YLLPLGEQLP DVSLTFQAWR RLSDPERLCF ISTTLQPFHA LLGGLGTQGR WTNMERMQLW AMRLDLRDLQ RHLRFQVLAA GFNLPEEEEE EEEEEEEERK GLLPGALGSA LQGPAQVSWP QLLSTYRLLH SLELVLSRAV RELLLLSKAG HSVWPLGFPT LSPQP EBI3 subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK |
| Molecular Weight | 47.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 90% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Stimulates proliferation of human TF-1 cells (ED50: 400–500 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IL-27 produced from HEK293 cells is a non-disulfide-linked, heterodimeric protein composed of a 209 amino acid EBI3 subunit and a 215 amino acid IL-27-p28 subunit, totaling 424 amino acid residues.
The calculated molecular weight of the associated IL-27 subunits is 47.8 kDa.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IL-27 (Interleukin 27) is a cytokine belonging to the IL-12 family, composed of EBI3 and p28 subunits. It is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines.
IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing T-bet expression and upregulating IL-12Rβ2, thereby suppressing Th2 and Th17 differentiation.
It acts via WSX-1 and gp130 receptors, activating the Jak/STAT signaling cascade involved in immune regulation.
IL-27 may have therapeutic potential against cancer through CD8+ T-cell mediated anti-tumor activity.
In humans, the IL-27 gene is located on the p arm of chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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