Thermo Fisher Scientific NFE2 Polyclonal Antibody
인간, 생쥐, 랫드에서 NFE2 단백질을 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. Affinity chromatography로 정제된 고품질 항체로, 액상 형태이며 PBS/glycerol buffer에 보관. 적혈구 및 거핵세포 분화 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFE2 (Accession Q16621), corresponding to amino acid residues R272–M322 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850377 |
Product Specific Information
Antibody detects endogenous levels of total NFE2.
Target Information
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation.
Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR).
This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters.
Requires MAFK or other small MAF proteins for binding to the NF-E2 motif.
May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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