Thermo Fisher Scientific ING3 Polyclonal Antibody
Human ING3 단백질을 인식하는 Rabbit Polyclonal 항체로, 세포면역형광(ICC/IF)에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ING3. Recombinant protein control fragment (Product #RP-105430) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664969 |
Product Specific Information
Immunogen sequence:
MLYLEDYLEMI EQLPMDLRDR FTEMREMDLQ VQNAMDQLEQ RVSEFFMNAK KNKPEWREEQ MASIKKDYYK ALEDADEKVQ LANQI
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, a common motif in chromatin remodeling-related proteins. It can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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