Thermo Fisher Scientific RAMP1 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The RAMP1 protein is a member of the RAMP family of single-transmembrane-domain proteins, known as receptor (calcitonin) activity modifying proteins (RAMPs).
RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
They are required for transporting calcitonin-receptor-like receptor (CRLR) to the plasma membrane.
CRLR can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on RAMP family expression.
In the presence of RAMP1, CRLR functions as a CGRP receptor.
RAMP1 is involved in terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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