Thermo Fisher Scientific Munc13-4 Polyclonal Antibody
Munc13-4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol) 내 0.1 mg/mL 농도로 제공됩니다. 인간 시료에 반응하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UNC13D. Recombinant protein control fragment (Product #RP-105417) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791896 |
Product Specific Information
Immunogen sequence:
SFHLDMWDLD TVESVRQKLG ELTDLHGLRR IFKEARKDKG QDDFLGNVVL RLQDLRCRED QWYPLEPRTE TYPDRGQCHL QFQLIHKRRA TSASRSQPSY TVHLHLLQQL VSHEVTQHEA GSTSWDGSLS PQAATVLFLH ATQKDLSD
Target Information
This gene encodes a protein that is a member of the UNC13 family, containing a similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein plays a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granule secretion.
Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a rare autosomal recessive disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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