Thermo Fisher Scientific TFAM Polyclonal Antibody
TFAM 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, 인간·마우스·랫트 반응성을 보입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 미토콘드리아 DNA 유지 및 발현 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 126–171 of Human TFAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803659 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Mitochondrial transcription factor A (TFAM) is a nuclear-encoded protein that is transported to mitochondria, where it plays a key role in maintaining and expressing mitochondrial DNA (mtDNA). TFAM regulates mtDNA replication and transcription, ensuring proper mitochondrial function. It contains an LC3 interacting region (LIR) motif that binds autophagy proteins such as LC3, aiding in removal of leaked mtDNA and limiting inflammation. TFAM levels vary by tissue, influencing oxidative phosphorylation (OXPHOS) capacity and mitochondrial genome stability. Disruptions in TFAM are associated with neurodegeneration and diseases related to mtDNA stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-86900_TFAM_Q00059-1_Rabbit.svg, PA5-86900_TFAM_Q00059-1_Rabbit_PDP.jpeg)
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