Thermo Fisher Scientific SP1 Monoclonal Antibody (4H6)
SP1 단백질을 표적으로 하는 Thermo Fisher Scientific의 4H6 클론 단일클론 항체. Western blot 및 ELISA에 적합하며 인간과 생쥐에 반응. 액상 형태로 제공되며 -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific SP1 Monoclonal Antibody (4H6)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- ELISA: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H6 |
| Immunogen | SP1 (NP_612482, 89–198 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GTGELDLTAT QLSQGANGWQ IISSSSGATP TSKEQSGSST NGSNGSESSK NRTVSGGQYV VAAAPNLQNQ QVLTGLPGVM PNIQYQVIPQ FQTVDGQQLQ FAATGAQVQQ
Target Information
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.
It binds with high affinity to GC-rich motifs and regulates the expression of numerous genes involved in processes such as:
- Cell growth
- Apoptosis
- Differentiation
- Immune responses
SP1 is highly regulated by post-translational modifications including phosphorylation, sumoylation, proteolytic cleavage, glycosylation, and acetylation.
It also binds the PDGFR-alpha G-box promoter and may modulate cellular response to DNA damage.
SP1 is implicated in chromatin remodeling and plays a role in recruitment of SMARCA4/BRG1 on the c-FOS promoter, as well as regulation of FE65 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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