Thermo Fisher Scientific SP1 Monoclonal Antibody (4H6)

Thermo Fisher Scientific SP1 Monoclonal Antibody (4H6)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• ELISA: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
GTGELDLTAT QLSQGANGWQ IISSSSGATP TSKEQSGSST NGSNGSESSK NRTVSGGQYV VAAAPNLQNQ QVLTGLPGVM PNIQYQVIPQ FQTVDGQQLQ FAATGAQVQQ

Target Information

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.
It binds with high affinity to GC-rich motifs and regulates the expression of numerous genes involved in processes such as:

• Cell growth
• Apoptosis
• Differentiation
• Immune responses

SP1 is highly regulated by post-translational modifications including phosphorylation, sumoylation, proteolytic cleavage, glycosylation, and acetylation.
It also binds the PDGFR-alpha G-box promoter and may modulate cellular response to DNA damage.
SP1 is implicated in chromatin remodeling and plays a role in recruitment of SMARCA4/BRG1 on the c-FOS promoter, as well as regulation of FE65 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.