Thermo Fisher Scientific FALZ/BPTF Polyclonal Antibody
FALZ/BPTF 단백질을 인식하는 Thermo Fisher Scientific의 고품질 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합하며 항원 친화 크로마토그래피로 정제됨. 인간 반응성, 액상 형태, 연구용 전용.
- 카탈로그번호
- A300973A
- 판매단위
- pk
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Thermo Fisher Scientific FALZ/BPTF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1350 and 1400 of human Fetal Alzheimer Antigen (Bromodomain and PHD Domain Transcription Factor) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription.
BPTF recognizes histone H3 tails that are tri-methylated at K4, marking transcriptional start sites of active genes, and binds also to H3 di-methylated at K4.
It plays a key role in early mouse embryo development, possibly through regulation of the Smad pathway.
BPTF is expressed at low levels in the adult brain and spinal cord but increases in neurodegenerative diseases, including Alzheimer’s disease.
It is abundantly expressed in the fetal brain and throughout the gray and white matter of the developing spinal cord (18–22 gestational weeks).
Tissue specificity: Ubiquitously expressed, highest levels in testis; present in kidney, liver, and brain, with highest levels in motor cortex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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